The Blonde in a Red Dress did some work with a UK trivia equivalent of “Ripley’s Believe it or Not”, probably based on her prior experience of dealing with skeletons and skulls.
Adventure #1099 (UK)
The ubiquitous cover girl of the Golden Age of comics!
I would normally assume that this cover was meant to be symbolic of the threat of death looming over a life of crime… but given the habit of the Blonde in a Red Dress to do stuff like chase after a witch’s hoard, I wouldn’t be surprised if this was an actual attack by a literal giant skull monster.
Punch Comics #12, Chesler